Dermal Absorption Model for Extrapolation

Dermal Absorption Model for Extrapolation

DAME

DAME is a model to calculate percentage systemic and total absorption based on an in vitro dermal absorption experimental set-up on the basis of a permeation constant kp, the molecular weight and octanol-water partioning coefficient log KOW. It is particular useful when finite dose exposure is concerned (=relatively low exposure).

https://doi.org/10.1016/j.yrtph.2010.02.008

2010, 2016

Buist HE, van Burgsteden JA, Freidig AP, Maas WJM, van de Sandt JJM. 2010. New in vitro dermal absorption database and the prediction of dermal absorption under finite conditions for risk assessment purposes. Regul. Toxicol. Pharmacol. 57, 200–209. Buist HE. 2016. Dermal absorption and toxicological risk assessment: pitfalls and promises. PhD thesis, Wageningen University, Wageningen, the Netherlands. Available via https://edepot.wur.nl/370088.